NORDBIOTIC™ 4 SKIN

4 Strains for Skin

Beauty from Within

The Gut – Skin Axis

Skin health is linked to intestinal microbiota through the gut–skin axis, a bidirectional network integrating immune, metabolic, and barrier-related pathways. 

Disturbances in gut microbiota composition and intestinal barrier integrity are associated with inflammatory and functional skin disorders. 

Probiotics may influence these processes through antimicrobial activity, microbial metabolite production, and modulation of epithelial barrier physiology.

Because probiotic effects are strain-specific, combining strains with complementary activities may provide broader biological functionality than single-strain approaches.

NORDBIOTIC™ 4 SKIN was therefore developed as a multi-strain probiotic technology supporting the gut–skin axis.

The NORDBIOTIC™ 4 SKIN Concept

NORDBIOTIC™ 4 SKIN combines four probiotic strains selected through integrated functional and metabolomic screening for their complementary biological activities.

L. paracasei LPC100

L. acidophilus LA120

L. fermentum LF160

B. bifidum BF030

Functional profiling demonstrated that different strains contribute distinct biological activities, supporting the rationale for a complementary multi-strain formulation.

Complementary functional profiles

Functional Heatmap of NORDBIOTIC™ 4 SKIN Strains

FUNCTIONAL ACTIVITY	LPC 100	LA 120	LF 160	BF 030
Antagonism vs skin pathogens (S. aureus, Cutibacterium)
Lactate production
Succinate / arginine metabolism
Amino acid production (glycine, glutamine, proline)
B-vitamin metabolism (B3, B6)
Epithelial barrier support

Legend:

4 Key Functional Pillars

1. Antagonism Against Skin-Associated Microorganisms

Antimicrobial activity against opportunistic skin-associated bacteria was strain-dependent.

L. fermentum LF160

showed the broadest inhibition spectrum against Staphylococcus aureus and Cutibacterium species.

L. paracasei LPC100

demonstrated targeted inhibition of Cutibacterium strains.

L. acidophilus LA120

exhibited moderate activity against selected strains.

Together, these complementary antimicrobial profiles broaden the capacity of the formulation to counteract microorganisms associated with skin imbalance.

2. Production of Microbial Metabolites

Metabolomic profiling identified several metabolites produced by the selected strains involved in host– microbe metabolic interactions.

Organic Acids

Lactate produced by lactobacilli contributes to microbial ecological balance and epithelial physiology. Succinate, produced at elevated levels by   L. fermentum LF160, represents an additional microbial signaling metabolite associated with host metabolic communication.

Amino acids associated with epithelial and skin metabolism

Metabolomic analysis identified production of several amino acids across the NORDBIOTIC™ 4 SKIN strains, including:

Glycine Proline

Glutamine

Cysteine Arginine

Ornithine

These metabolites are involved in epithelial physiology, collagen structure, antioxidant pathways, and host metabolic signaling.

3. B-Vitamin Metabolism

Metabolomic analysis indicated production of selected B-vitamins by the NORDBIOTIC™ 4 SKIN strains.

Vitamin B3 (niacin)
was associated with L. acidophilus LA120, L. fermentum LF160, L. paracasei LPC100 and B. bifidum BF030

Vitamin B6
production was associated particularly with B. bifidum BF030. These vitamins participate in metabolic pathways relevant to epithelial cell function.

These vitamins participate in metabolic pathways relevant to epithelial cell function.

4. Support of Epithelial Barrier Physiology

Functional screening showed activities associated with epithelial barrier support.

Maintenance of intestinal barrier integrity plays an important role in host–microbiome interactions and may contribute to systemic processes linked to skin physiology.

Why 4 strains are better than one for supporting skin health?

Functional and metabolomic profiling demonstrated that key probiotic activities — including antimicrobial effects, metabolite production, and epithelial barrier-associated functions — are distributed across multiple strains.

A multi-strain formulation therefore enables integration of complementary biological mechanisms, providing broader functional coverage than single-strain probiotic approaches. NORDBIOTIC™ 4 SKIN leverages this complementarity to support multi-mechanistic modulation of the gut–skin axis.

KEY INGREDIENTS

TYPE

CONCLUSION

NORDBIOTIC™ 4 SKIN represents a science-driven probiotic technology developed through integrated functional and metabolomic profiling.

By combining four carefully selected strains with complementary antimicrobial and metabolic properties, this formulation provides multi-mechanistic support for gut–skin axis modulation, offering a rational platform for next-generation probiotic supplements targeting skin health.

The science behind Probiotic 4 Skin

For more information and inquiries

This website contains information about the research and development activities of Nordic Biotic Sp. z o.o. relating to food products in the form of probiotic preparations. In particular, it is intended to describe and summarize the results of scientific studies organized by the company on such preparations.

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Do not relate to medicinal products, including the organization of clinical studies, research and development activities, manufacture, or offering of medicinal products or their components, including active pharmaceutical ingredients.
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